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- Table of Contents
Facts about Sphingomyelin phosphodiesterase 3.
Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells.
Human | |
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Gene Name: | SMPD3 |
Uniprot: | Q9NY59 |
Entrez: | 55512 |
Belongs to: |
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neutral sphingomyelinase family |
EC 3.1.4.12; FLJ22593; MGC138443; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; NSMASE2; nSMase-2; SMPD3; sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinaseII)
Mass (kDA):
71.081 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (68358327..68448703, complement) |
Predominantly expressed in brain.
Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:10823942). Localizes to plasma membrane in confluent contact-inhaibited cells (PubMed:15051724).
PMID: 10823942 by Hofmann K., et al. Cloning and characterization of the mammalian brain-specific, Mg2+- dependent neutral sphingomyelinase.
PMID: 14741383 by Miura Y., et al. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.