SMPDL3A Antibodies

AND SMPDL3A ELISA kits, SMPDL3A Proteins

Many biological assays use antibodies to detect SMPDL3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMPDL3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMPDL3A antibodies...

We validate the specificity of these antibodies to SMPDL3A by testing them on tissues known to express SMPDL3A positively and negatively. Browse below to find the SMPDL3A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMPDL3A Infographic by Boster Bio

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SMPDL3A (NM_006714) Human Over-expression Lysate

Human

$628
Cat # LS010924
20 µg, 100 µg

SMPDL3A Overview

Facts about Acid sphingomyelinase-like phosphodiesterase 3a.

SMPDL3A 3D structure. Source: alphafold

Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A)

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789).

Has lower action with nucleoside diphosphates, and no action with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine.

Gene Information

Human
Gene Name:	SMPDL3A
Uniprot:	Q92484
Entrez:	10924

Family

Belongs to:

acid sphingomyelinase family

Alternative Names

0610010C24Rik; acid sphingomyelinase-like phosphodiesterase 3a; ASM3A; ASML3A; ASM-like phosphodiesterase 3a; EC 3.1.4; EC 3.1.4.-; FLJ20177; SMPDL3A; sphingomyelin phosphodiesterase, acid-like 3A; yR36GH4.1

Molecular Weight

Mass (kDA):
51.26 kDA

Genomic Context


Human

Location:	6q22.31
Sequence:	6; NC_000006.12 (122788456..122809720)

Tissue Specificity

Detected in blood serum. Detected in macrophages (at protein level).

Subcellular Localizations

Secreted.

Diseases

Bladder Neoplasm
Cell Transformation, Neoplastic
Malignant Neoplasms
Neoplasms
Atherosclerosis
Malignant Neoplasm Of Urinary Bladder

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMPDL3A

References

PMID: 25288789 by Traini M., et al. Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages.

PMID: 26783088 by Lim S.M., et al. The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homolog with a novel nucleotide hydrolase activity.