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Synphilin-1 Antibodies

AND SNCAIP ELISA kits, Synphilin-1 Proteins

Many biological assays use antibodies to detect Synphilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Synphilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Synphilin-1 antibodies...

We validate the specificity of these antibodies to Synphilin-1 by testing them on tissues known to express SNCAIP positively and negatively. Browse below to find the SNCAIP antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SNCAIP Infographic by Boster Bio

SNCAIP protein infographic

All SNCAIP Products

Product

Figures

Specificity

Applications

Price

Anti-Synphilin-1 (R846) SNCAIP Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A04107
100ul

Synphilin 1 (SNCAIP) (NM_005460) Human Over-expression Lysate

Human

$960
Cat # LS009627
100 µg

SNCAIP Overview

Facts about Synphilin-1.

SNCAIP 3D structure

SNCAIP 3D structure. Source: alphafold

Synphilin-1 (SNCAIP)

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH.

Isoform 2 modulates SNCA monoubiquitination by SIAH1. .

Gene Information

Human
Gene Name:	SNCAIP
Uniprot:	Q9Y6H5
Entrez:	9627

Gene Information

Family

Belongs to:

No superfamily

Family

Alternative Names

Alpha-synuclein-interacting protein; MGC39814; Sph1; synphilin-1; synuclein, alpha interacting protein; SYPH1

Molecular Weight

Mass (kDA):
100.409 kDA

Molecular Weight

Genomic Context


Human

Location:	5q23.2
Sequence:	5; NC_000005.10 (122311354..122464219)

Tissue Specificity

Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta.

Subcellular Localizations

Cytoplasm. Detected in cytoplasmic inclusion bodies, together with SNCA.

Subcellular Localization

Diseases

Parkinson Disease
Neurodegenerative Disorders
Lewy Body Disease
Dementia
Alzheimer's Disease
Secondary Parkinson Disease
Nerve Degeneration
Multiple System Atrophy
Neuroblastoma
Atrophy
Juvenile Parkinson's Disease
Nervousness

Movement Disorders
Neoplasms
Neurofibrillary Tangles
Dysequilibrium Syndrome
Physiological Stress
Plaque, Amyloid
Frontotemporal Dementia

Disease

Interacting Proteins

SNCA

Interacting Proteins

Pathways

Pathogenesis
Cell Death
Transport
Localization
Autophagy
Aging
Protein Phosphorylation
Cellular Homeostasis
Regulation Of Signaling
Proteolysis
Synaptic Transmission
Intracellular Signal Transduction

Translation
Protein Refolding
Necrotic Cell Death
Cell Differentiation
Cell Growth
Response To Nutrient

Pathways

PTMs

Ubiquitination
Phosphorylation

Cleavage
Nitrosylation

Research Areas

Alzheimers Research
Neuroscience

Research Areas

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNCAIP

References

PMID: 10319874 by Engelender S., et al. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

PMID: 10967135 by Engelender S., et al. Organization of the human synphilin-1 gene, a candidate for Parkinson's disease.