Sorting nexin-33 (Snx33)

Plays a role in the reorganization of the cytoskeleton, endocytosis and mobile vesicle trafficking through its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions.

Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides.