Suppressor of cytokine signaling 4 (Socs4)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition element of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Inhibits EGF signaling by mediating the degradation of this Tyr-phosphorylated EGF receptor/EGFR (By similarity). .