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- Table of Contents
Sortilin-related receptor Antibodies
AND SORL1 ELISA kits, Sortilin-related receptor Proteins
Many biological assays use antibodies to detect Sortilin-related receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sortilin-related receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sortilin-related receptor antibodies...
Designing a Western blot for Sortilin-related receptor? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SORL1 Western Blot GuideDesigning an IHC experiment for Sortilin-related receptor? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SORL1 IHC GuideSORL1 Infographic by Boster Bio
All SORL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01887-1
100 μg/vial
Cat # A01887-1
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC1937
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1937
1 kit, containing two 96-well plates and all necessary reagents
SORL1 Overview
Facts about Sortilin-related receptor.
Sortilin-related receptor (SORL1)
Likely to be a multifunctional endocytic receptor, which might be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the significant cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.
Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction.
Gene Information
| Human | |
|---|---|
| Gene Name: | SORL1 |
| Uniprot: | Q92673 |
| Entrez: | 6653 |
Family
| Belongs to: |
|---|
| VPS10-related sortilin family |
Alternative Names
C11orf32; chromosome 11 open reading frame 32; FLJ21930; FLJ39258; gp250; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LR11LDLR relative with 11 ligand-binding repeats; LRP9; mosaic protein LR11; SORL1; SorLA; SorLA-1SORLA; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; sortilin-related receptor, L(DLR class) A repeats-containing; Sorting protein-related receptor containing LDLR class A repeats
Molecular Weight
Mass (kDA):
248.426 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q24.1 |
| Sequence: | 11; NC_000011.10 (121452314..121633763) |
Tissue Specificity
Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
Subcellular Localizations
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I mem
Diseases
- Alzheimer's Disease
- Dementia
- Neurodegenerative Disorders
- Dental Plaque
- Atherosclerosis
- Nervousness
- Impaired Cognition
- Nerve Degeneration
- Tissue Adhesions
- Senile Plaques
- Plaque, Amyloid
- Mild Cognitive Disorder
- Hyperplasia
Interacting Proteins
- APP
- GGA1
- HSPA12A
Pathways
- Pathogenesis
- Transport
- Localization
- Intracellular Transport
- Cell Proliferation
- Endocytosis
- Secretion
- Aging
- Protein Processing
- Neurogenesis
- Inflammatory Response
- Cognition
- Mitosis
PTMs
- Cleavage
- Phosphorylation
- Ribosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SORL1
bosterbio.com/bosterbio-gene-info-cards/SORL1
References
PMID: 9157966 by Morwald S., et al. A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens.
PMID: 8940146 by Jacobsen L., et al. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.