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Transcription factor Sp3 Antibodies
AND SP3 ELISA kits, Transcription factor Sp3 Proteins
Many biological assays use antibodies to detect Transcription factor Sp3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor Sp3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor Sp3 antibodies...
Designing a Western blot for Transcription factor Sp3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SP3 Western Blot GuideSP3 Infographic by Boster Bio
All SP3 Products
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SP3 Overview
Facts about Transcription factor Sp3.
Transcription factor Sp3 (SP3)
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements.
Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.
Gene Information
| Human | |
|---|---|
| Gene Name: | SP3 |
| Uniprot: | Q02447 |
| Entrez: | 6670 |
Family
| Belongs to: |
|---|
| Sp1 C2H2-type zinc-finger protein family |
Alternative Names
DKFZp686O1631; GC-binding transcription factor Sp3; Sp3 transcription factor; Sp3; specificity protein 3; SPR2; SPR-2; transcription factor Sp3
Molecular Weight
Mass (kDA):
81.925 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.1 |
| Sequence: | 2; NC_000002.12 (173900775..173965702, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus. Nucleus, PML body. Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Traditional Serrated Adenoma
- Liver Carcinoma
- Tumor Angiogenesis
- Leukemia
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Neuroblastoma
Interacting Proteins
- ESR1
Pathways
- Methylation
- Translation
- Cell Cycle
- Pathogenesis
- Angiogenesis
- Cell Proliferation
- Cell Growth
- Secretion
- Rna Interference
- Cell Differentiation
- Localization
- Dna Methylation
- Transport
PTMs
- Phosphorylation
- Methylation
- Acetylation
- Cleavage
- Oxidation
- Dephosphorylation
- Demethylation
- Deacetylation
- Sumoylation
- Amination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP3
bosterbio.com/bosterbio-gene-info-cards/SP3
References
PMID: 12297010 by Hernandez E.M., et al. AUA as a translation initiation site in vitro for the human transcription factor Sp3.
PMID: 15474306 by Moran K.M., et al. Human transcription factor Sp3: genomic structure, identification of a processed pseudogene, and transcript analysis.