SPCS3 Antibodies

AND SPCS3 ELISA kits, SPCS3 Proteins

Many biological assays use antibodies to detect SPCS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPCS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPCS3 antibodies...

We validate the specificity of these antibodies to SPCS3 by testing them on tissues known to express SPCS3 positively and negatively. Browse below to find the SPCS3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPCS3 Infographic by Boster Bio

All SPCS3 Products

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SPCS3 (NM_021928) Human Recombinant Protein

Coomassie blue staining of purified SPCS3 protein

$1249
Cat # PROTP61009
20 µg

SPCS3 (NM_021928) Human Over-expression Lysate

Human

$628
Cat # LS060559
20 µg, 100 µg

SPCS3 Overview

Facts about Signal peptidase complex subunit 3.

SPCS3 3D structure. Source: alphafold

Signal peptidase complex subunit 3 (SPCS3)

Part of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. .

Gene Information

Human
Gene Name:	SPCS3
Uniprot:	P61009
Entrez:	60559

Family

Belongs to:

SPCS3 family

Alternative Names

DKFZp564J1864; EC 3.4; Microsomal signal peptidase 22/23 kDa subunit; microsomal signal peptidase 23 kDa subunit; PRO3567; signal peptidase complex subunit 3 homolog (S. cerevisiae); signal peptidase complex subunit 3; SPase 22 kDa subunit; SPase 22/23 kDa subunit; SPC22; SPC22/23FLJ22649; SPC3; YLR066W

Molecular Weight

Mass (kDA):
20.313 kDA

Genomic Context


Human

Location:	4q34.2
Sequence:	4; NC_000004.12 (176319966..176332245)

Subcellular Localizations

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Pathways

Transport
Cartilage Development
Reverse Transcription
Chondrocyte Development
Bone Development
Chondrocyte Differentiation

Rna Interference

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPCS3

References

PMID: 27499293 by Chen Q., et al. Inverting the topology of a transmembrane protein by regulating the translocation of the first transmembrane helix.

PMID: 27383988 by Zhang R., et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.