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- Table of Contents
Facts about Speedy protein C.
Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the right localization of the active form of Aurora B in prometaphase.
Human | |
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Gene Name: | SPDYC |
Uniprot: | Q5MJ68 |
Entrez: | 387778 |
Belongs to: |
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Speedy/Ringo family |
hSpy/Ringo C; Rapid inducer of G2/M progression in oocytes C; RINGO C; Ringo2; speedy C; speedy homolog C (Xenopus laevis); speedy protein C
Mass (kDA):
33.166 kDA
Human | |
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Location: | 11q13.1 |
Sequence: | 11; NC_000011.10 (65170154..65173666) |
Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.
Cytoplasm. Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.
PMID: 15611625 by Cheng A., et al. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.
PMID: 20605920 by Mouron S., et al. RINGO C is required to sustain the spindle-assembly checkpoint.