SPPL2B Antibodies

AND SPPL2B ELISA kits, SPPL2B Proteins

Many biological assays use antibodies to detect SPPL2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPPL2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPPL2B antibodies...

We validate the specificity of these antibodies to SPPL2B by testing them on tissues known to express SPPL2B positively and negatively. Browse below to find the SPPL2B antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: SMCO4

SPPL2B Infographic by Boster Bio

All SPPL2B Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

SPPL2B Overview

Facts about Signal peptide peptidase-like 2B.

SPPL2B 3D structure. Source: alphafold

Signal peptide peptidase-like 2B (SPPL2B)

Intramembrane-cleaving aspartic protease (I-CLiP) which cleaves type II membrane signal peptides from the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595).

Catalyzes the intramembrane cleavage of the anchored fragment of discard TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952).

Gene Information

Human
Gene Name:	SPPL2B
Uniprot:	Q8TCT7
Entrez:	56928

Family

Belongs to:

peptidase A22B family

Alternative Names

EC 3.4.23; EC 3.4.23.-; IMP-4; IMP4MGC111084; Intramembrane protease 4; KIAA1532signal peptide peptidase-like 2B; Presenilin-like protein 1; PSL1; SNPPL2B; SPPL2b; SPP-like 2B

Molecular Weight

Mass (kDA):
64.644 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (2328571..2355095)

Tissue Specificity

Expressed predominantly in adrenal cortex and mammary gland.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. targeted through the entire secretory pathway to endosomes/lysosomes (PubMed:15998642).

Diseases

Nervousness
Dementia
Myeloproliferative Syndrome, Transient
Malaria
Alzheimer's Disease
Malaria, Falciparum

Alzheimer Disease, Familial

Pathways

Proteolysis
Secretory Pathway
Cell Death
Localization
Transport
Nodal Signaling Pathway

Lysosomal Transport

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPPL2B

References

PMID: 12139484 by Grigorenko A.P., et al. Novel class of polytopic proteins with domains associated with putative protease activity.

PMID: 15385547 by Friedmann E., et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.