SPPL2C Antibodies

AND SPPL2C ELISA kits, SPPL2C Proteins

Many biological assays use antibodies to detect SPPL2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPPL2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPPL2C antibodies...

We validate the specificity of these antibodies to SPPL2C by testing them on tissues known to express SPPL2C positively and negatively. Browse below to find the SPPL2C antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPPL2C Infographic by Boster Bio

All SPPL2C Products

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Anti-IMP5/SPPL2C Antibody

Human

ELISA, IP, IF, IHC, ICC, WB

$370
Cat # A12664-1
100 μl/vial

SPPL2C Overview

Facts about Signal peptide peptidase-like 2C.

SPPL2C 3D structure. Source: alphafold

Signal peptide peptidase-like 2C (SPPL2C)

Intramembrane-cleaving aspartic protease (I-CLiP) that might have the ability to cleave type II membrane signal peptides in the hydrophobic plane of the membrane. .

Gene Information

Human
Gene Name:	SPPL2C
Uniprot:	Q8IUH8
Entrez:	162540

Family

Belongs to:

peptidase A22B family

Alternative Names

EC 3.4.23; EC 3.4.23.-; IMP-5; intramembrane protease 5; signal peptide peptidase-like 2C; SPPL2c; SPP-like 2C

Molecular Weight

Mass (kDA):
74.503 kDA

Genomic Context


Human

Location:	17q21.31
Sequence:	17; NC_000017.11 (45844881..45847067)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.

Diseases

Dementia

Pathways

Proteolysis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPPL2C

References

PMID: 12139484 by Grigorenko A.P., et al. Novel class of polytopic proteins with domains associated with putative protease activity.

PMID: 15385547 by Friedmann E., et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.