SPTAN1 Antibodies

AND SPTAN1 ELISA kits, SPTAN1 Proteins

Many biological assays use antibodies to detect SPTAN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTAN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTAN1 antibodies...

We validate the specificity of these antibodies to SPTAN1 by testing them on tissues known to express SPTAN1 positively and negatively. Browse below to find the SPTAN1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SPTAN1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SPTAN1 Western Blot Guide

SPTAN1 Infographic by Boster Bio

All SPTAN1 Products

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Specificity

Applications

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Anti-NEAS/SPTAN1 Antibody Picoband®

Western blot analysis of NEAS/SPTAN1 using anti-NEAS/SPTAN1 antibody (A03831-3)

IHC analysis of NEAS/SPTAN1 using anti-NEAS/SPTAN1 antibody (A03831-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03831-3
100 μg/vial

Anti-SPTAN1 Antibody (Center)

Anti-SPTAN1 Antibody (Center) at 1:2000 dilution + human brain lysatesLysates/proteins at 20 µg per lane

Anti-SPTAN1 Antibody (Center) at 1:2000 dilution + SH-SY5Y whole cell lysatesLysates/proteins at 20 µg per lane

Human, Mouse, Rat

$299
Cat # M03831-1
80 µl

SPTAN1 Overview

Facts about Spectrin alpha chain, non-erythrocytic 1.

SPTAN1 3D structure. Source: alphafold

Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)

Fodrin, which appears to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent motion of the cytoskeleton at the membrane. .

Gene Information

Human
Gene Name:	SPTAN1
Uniprot:	Q13813
Entrez:	6709

Family

Belongs to:

spectrin family

Alternative Names

Alpha-II spectrin; EIEE5; FLJ17738; FLJ44613; Fodrin alpha chain; NEAS; spectrin alpha chain, brain; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Spectrin, non-erythroid alpha chain; SPTA2

Molecular Weight

Mass (kDA):
284.539 kDA

Genomic Context


Human

Location:	9q34.11
Sequence:	9; NC_000009.12 (128552564..128633662)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.

Diseases

Epilepsy
Infantile Spasms
Encephalopathies
Spasm
Dysplasia
Developmental Delay (disorder)
Malignant Neoplasms
Cerebral Atrophy
Atrophy
Muscle Hypotonia
Haploinsufficiency

Stomach Neoplasms
Malnutrition
Metaplasia
Hereditary Hemorrhagic Telangiectasia
Early Infantile Epileptic Encephalopathy With Burst-suppression
Strabismus

Interacting Proteins

DISC1
EVL
FANCG
MLH1
SPTBN1

Pathways

Pathogenesis
Cell Cycle
Tissue Development
Cell Proliferation
Response To Hypoxia
Dna Repair
Endocytosis
Angiogenesis

Localization
Myelination

PTMs

Acetylation

Phosphoprotein

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTAN1

References

PMID: 2307671 by Moon R.T., et al. Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin.

PMID: 10625438 by Cianci C.D., et al. Brain and muscle express a unique alternative transcript of alphaII spectrin.