This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SPTBN1 Antibodies
AND SPTBN1 ELISA kits, SPTBN1 Proteins
Many biological assays use antibodies to detect SPTBN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTBN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTBN1 antibodies...
Designing a Western blot for SPTBN1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPTBN1 Western Blot GuideDesigning an IHC experiment for SPTBN1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SPTBN1 IHC GuideSPTBN1 Infographic by Boster Bio
All SPTBN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M03164-1
20μL, 40μL, 100μL, 200μL
Cat # M03164-1
20μL, 40μL, 100μL, 200μL
SPTBN1 Overview
Facts about Spectrin beta chain, non-erythrocytic 1.
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SPTBN1 |
| Uniprot: | Q01082 |
| Entrez: | 6711 |
Family
| Belongs to: |
|---|
| spectrin family |
Alternative Names
beta-fodrin; beta-G spectrin; Beta-II spectrin; beta-spectrin 2; beta-spectrin II; betaSpII; ELF; embryonic liver beta-fodrin; Fodrin beta chain; spectrin beta chain, brain 1; spectrin, beta, non-erythrocytic 1; Spectrin, non-erythroid beta chain 1; SPTB2
Molecular Weight
Mass (kDA):
274.609 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p16.2 |
| Sequence: | 2; NC_000002.12 (54456327..54671446) |
Tissue Specificity
Isoform 2 is present in brain, lung and kidney (at protein level).
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line. Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Diseases
- Neoplasms
- Fracture
- Malignant Neoplasms
- Osteoporosis
- Osteoporotic Fractures
- Carcinoma
- Neoplastic Syndromes, Hereditary
- Malignant Neoplasm Of Pancreas
- Cytogenetic Abnormality
- Myeloproliferative Disease
- Retinal Dystrophies
- Neoplasm Metastasis
Interacting Proteins
- CDC5L
- DISC1
- SPTA1
- SPTAN1
Pathways
- Localization
- Ossification
- Pathogenesis
- Cell Adhesion
- Osteoclast Differentiation
- Cell Activation
- Cell Migration
- Cell Proliferation
- Endochondral Ossification
- Stem Cell Differentiation
- T Cell Activation
- Mitosis
- Proteolysis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTBN1
bosterbio.com/bosterbio-gene-info-cards/SPTBN1
References
PMID: 1527002 by Hu R.J., et al. Characterization of human brain cDNA encoding the general isoform of beta-spectrin.
PMID: 11665863 by Chen Y., et al. A novel isoform of beta-spectrin II localizes to cerebellar Purkinje- cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin.