SRRM1 Antibodies

AND SRRM1 ELISA kits, SRRM1 Proteins

Many biological assays use antibodies to detect SRRM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRRM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRRM1 antibodies...

We validate the specificity of these antibodies to SRRM1 by testing them on tissues known to express SRRM1 positively and negatively. Browse below to find the SRRM1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for SRRM1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SRRM1 IHC Guide

SRRM1 Infographic by Boster Bio

All SRRM1 Products

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Specificity

Applications

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Anti-SRRM1 Antibody

Western blot analysis of extracts of various cell lines, using SRRM1 antibody at 1:3000 dilution

Immunohistochemistry of paraffin-embedded human esophageal cancer using SRRM1 Rabbit pAb at dilution of 1:450

Immunohistochemistry of paraffin-embedded mouse testis using SRRM1 Rabbit pAb at dilution of 1:450

Human, Mouse

IHC, WB

$405
Cat # A07296
100ul

SRRM1 (NM_005839) Human Over-expression Lysate

Human

$628
Cat # LS010250
20 µg, 100 µg

SRRM1 Overview

Facts about Serine/arginine repetitive matrix protein 1.

SRRM1 3D structure. Source: alphafold

Serine/arginine repetitive matrix protein 1 (SRRM1)

Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events.

Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) variables of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex.

Gene Information

Human
Gene Name:	SRRM1
Uniprot:	Q8IYB3
Entrez:	10250

Family

Belongs to:

splicing factor SR family

Alternative Names

MGC39488; POP101; Ser/Arg-related nuclear matrix protein; serine/arginine repetitive matrix 1; serine/arginine repetitive matrix protein 1; SRm160; SRM160160-KD; SR-related nuclear matrix protein of 160 kDa

Molecular Weight

Mass (kDA):
102.335 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (24643273..24673281)

Subcellular Localizations

Nucleus matrix. Nucleus speckle.

Diseases

Leukemia
Cell Invasion
Neoplasm Invasiveness
Rheumatism
Leukemia, Myelocytic, Acute
Arthritis
Malignant Neoplasms
Autoimmune Reaction
Neoplasms
Myeloid Leukemia
Diffuse Large B-cell Lymphoma

Genetic Diseases, Inborn
Cytoplasmic Accumulation
Chromosomal Translocation
Liposarcoma
Rheumatoid Arthritis
Arthritis, Juvenile Rheumatoid

Interacting Proteins

CLK2

Pathways

Translation
Rna Interference
Rna Splicing
Transport
Mrna Transcription
Sister Chromatid Cohesion
Nucleocytoplasmic Transport

Mrna Transport
Localization

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRRM1

References

PMID: 9531537 by Blencowe B.J., et al. A coactivator of pre-mRNA splicing.

PMID: 10339552 by Eldridge A.G., et al. The SRm160/300 splicing coactivator is required for exon-enhancer function.