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- Table of Contents
Protein SSXT Antibodies
AND SS18 ELISA kits, Protein SSXT Proteins
Many biological assays use antibodies to detect Protein SSXT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein SSXT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein SSXT antibodies...
Designing an IHC experiment for Protein SSXT? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SS18 IHC GuideSS18 Infographic by Boster Bio
All SS18 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1822
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1822
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2552
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2552
1 kit, containing two 96-well plates and all necessary reagents
Human
$628
Cat # LS026039
20 µg, 100 µg
Cat # LS026039
20 µg, 100 µg
SS18 Overview
Facts about Protein SSXT.
Protein SSXT (SS18)
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation.
Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic actions, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Gene Information
| Human | |
|---|---|
| Gene Name: | SS18 |
| Uniprot: | Q15532 |
| Entrez: | 6760 |
Family
| Belongs to: |
|---|
| SS18 family |
Alternative Names
MGC116875; Protein SYT; SSXTsynovial sarcoma, translocated to X chromosome; Synovial sarcoma translocated to X chromosome protein; synovial sarcoma translocation, chromosome 18; SYTprotein SSXT
Molecular Weight
Mass (kDA):
45.929 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (26016253..26091217, complement) |
Tissue Specificity
Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
Subcellular Localizations
Nucleus.
Diseases
- Synovial Sarcoma
- Sarcoma
- Neoplasms
- Chromosomal Translocation
- Soft Tissue Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasms
- Neoplasm Metastasis
- Neoplasms, Fibrous Tissue
- Bone Neoplasms
- Tissue Adhesions
- Carcinoma
Interacting Proteins
- ATF2
Pathways
- Reverse Transcription
- Localization
- Interphase
- Chromatin Remodeling
- Cell Adhesion
- Metaphase
- Cell Proliferation
- Mitosis
- Pathogenesis
- Cell Migration
- Dna Repair
- Dna Methylation
PTMs
- Methylation
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SS18
bosterbio.com/bosterbio-gene-info-cards/SS18
References
PMID: 7951320 by Clark J., et al. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.
PMID: 11368913 by Brodin B., et al. Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression.