SH3 and cysteine-rich domain-containing protein 3 (Stac3)

Required for normal excitation-contraction coupling in skeletal muscle and also for muscle contraction in response to membrane depolarization (PubMed:23818578, PubMed:27621462). Required for normal Ca(2+) release in the sarcplasmic reticulum, which ultimately leads to muscle contraction (PubMed:23818578).

Probably works via its effects on muscle calcium channels. Increases CACNA1S channel activity, as well as its role in improving the expression of CACNA1S at the cell membrane (PubMed:27621462).