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Facts about Signal transducer and activator of transcription 5B.
Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Human | |
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Gene Name: | STAT5B |
Uniprot: | P51692 |
Entrez: | 6777 |
Belongs to: |
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transcription factor STAT family |
signal transducer and activator of transcription 5B; STAT5; STAT5b; transcription factor STAT5B
Mass (kDA):
89.866 kDA
Human | |
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Location: | 17q21.2 |
Sequence: | 17; NC_000017.11 (42199177..42288437, complement) |
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
If you're looking for information about Boster Bio: STAT5B Marker If so, then you've come to the right place. This article will provide advantages and benefits of Boster Bio:STAT5B Marker. We will also look at the Boster Bio STAT5B Antibody. Continue reading to discover more about the advantages of this product. It can be utilized in a variety of ways and you'll feel comfortable knowing that you have made an investment in a top-quality product.
A company located in Wuhan, Hubei China produces anti-STAT5b antibodies. The Boster Bio Anti-STAT5b antibody has been developed by the company to identify the marker in cell cultures. The STAT5B marker is a cellular signaling protein that plays an essential role in the cell cycle. A number of researchers have reported positive results using this antibody.
The antibody was tested using mouse splenocytes and mouse Thymocytes. The recommended dosage is 0.25 ug for each test, approximately 100 uL. The number of cells should be determined by observation, however it may range from 105-108 cells per test. To ensure that the test is performed at its best the anti-STAT5B antigen must be adjusted by comparing the results of immunostaining using ab125938. Based on three independent tests using flow cytometric analysis, the method was used to quantify the number cells in each group.
The STAT5B gene is a highly conserved, universal marker of genes that is found in a variety of tissues. Its primary function is to regulate the growth of T cells. Without the STAT5B protein, cells cannot differentiate between CD4+ and CD8+ T cells. The gene is able to be overexpressed in T cells, which may cause them to transform into aneoplastic cells and increase their number and destruction. STAT5B, which is found in the thymus, is able to rescue Treg cells from differentiation in T cells that lack the IL-2R.
PMID: 8732682 by Silva C.M., et al. Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.
PMID: 8631883 by Lin J.-X., et al. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.
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