Store-operated calcium entry regulator STIMATE (Stimate)

Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites which join the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores.

Acts by interacting with STIM1, boosting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions.