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- Table of Contents
STK24 Antibodies
AND STK24 ELISA kits, STK24 Proteins
Many biological assays use antibodies to detect STK24, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STK24 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STK24 antibodies...
Designing an IHC experiment for STK24? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the STK24 IHC GuideSTK24 Infographic by Boster Bio
All STK24 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A04112-3
100 μg/vial
Cat # A04112-3
100 μg/vial
STK24 Overview
Facts about Serine/threonine-protein kinase 24.
Serine/threonine-protein kinase 24 (STK24)
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by regulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress.
Plays a part in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity connected with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | STK24 |
| Uniprot: | Q9Y6E0 |
| Entrez: | 8428 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; Mammalian STE20-like protein kinase 3; MST-3; MST3serine/threonine kinase 24 (Ste20, yeast homolog); serine/threonine kinase 24; serine/threonine-protein kinase 24; STE20; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; STK3yeast)
Molecular Weight
Mass (kDA):
49.308 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q32.2 |
| Sequence: | 13; NC_000013.11 (98450199..98577151, complement) |
Tissue Specificity
Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
Subcellular Localizations
Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Diseases
- Cavernous Hemangioma Of Brain
- Malignant Neoplasms
- Neoplasms
- Adenocarcinoma
- Hemangioma, Cavernous, Central Nervous System
- Adenoma
- Spinal Cord Injuries
- Pediatric Neoplasm
- Labor Pain
- Trinucleotide Repeat Expansion
- Colonic Neoplasms
- Ataxia
- Hypoxia
Interacting Proteins
- CTTNBP2NL
- PDCD10
- STRIP1
- STRN
- TRAF3IP3
Pathways
- Apoptotic Process
- Regulation Of Cell Cycle
- Cell Proliferation
- Golgi Localization
- Induction Of Apoptosis
- Axon Regeneration
- Dna Repair
- Response To Staurosporine
- Localization
- Regeneration
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STK24
bosterbio.com/bosterbio-gene-info-cards/STK24
References
PMID: 9353338 by Schinkmann K., et al. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.
PMID: 10644707 by Zhou T.-H., et al. Identification of a human brain-specific isoform of mammalian STE20- like kinase 3 that is regulated by cAMP-dependent protein kinase.