CST complex subunit STN1 Antibodies

AND STN1 ELISA kits, CST complex subunit STN1 Proteins

Many biological assays use antibodies to detect CST complex subunit STN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CST complex subunit STN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CST complex subunit STN1 antibodies...

We validate the specificity of these antibodies to CST complex subunit STN1 by testing them on tissues known to express STN1 positively and negatively. Browse below to find the STN1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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STN1 Infographic by Boster Bio

All STN1 Products

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OBFC1 (STN1) (NM_024928) Human Recombinant Protein

Coomassie blue staining of purified STN1 protein

$1249
Cat # PROTQ9H668
20 µg

Anti-OBFC1 (STN1) Mouse Monoclonal Antibody [Clone ID: OTI2E4]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY OBFC1 (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (10ug) from 4 different cell lines by using anti-OBFC1 monoclonal antibody at 1:200 dilution

HEK293T cells transfected with either OBFC1 (Myc-DDK-tagged) overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-OBFC1 antibody (M32355)

Human

Flow Cytometry, IF, WB

$523
Cat # M32355
100 µl

OBFC1 (STN1) (NM_024928) Human Over-expression Lysate

Human

$628
Cat # LS079991
20 µg, 100 µg

STN1 Overview

Facts about CST complex subunit STN1.

STN1 3D structure. Source: alphafold

CST complex subunit STN1 (STN1)

Part of the CST complex proposed to act as a technical replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.

Initially the CST complex was proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex was shown to be involved in a number of aspects of telomere replication.

Gene Information

Human
Gene Name:	STN1
Uniprot:	Q9H668
Entrez:	79991

Family

Belongs to:

STN1 family

Alternative Names

AAF44; AAF-44; alpha accessory factor 44; bA541N10.2; CST complex subunit STN1; oligonucleotide/oligosaccharide-binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; replication protein A 32 kDa subunit; RP11-541N10.2; RPA-32; STN1FLJ22559; Suppressor of cdc thirteen homolog

Molecular Weight

Mass (kDA):
42.119 kDA

Genomic Context


Human

Location:	10q24.33
Sequence:	10; NC_000010.11 (103877569..103918184, complement)

Subcellular Localizations

Nucleus. Chromosome, telomere.

Diseases

Cardiovascular Diseases
Cholangiocarcinoma
Malignant Neoplasm Of Prostate
Anemia
Pulmonary Fibrosis
Telomere Shortening
Fibrosis
Malignant Neoplasms
Aplastic Anemia

Malignant Neoplasm Of Ovary
Dyskeratosis Congenita
Dysequilibrium Syndrome
Dyskeratosis

Interacting Proteins

ACD
CTC1
LDLRAP1
TEN1

Pathways

Telomere Maintenance
Senescence
Replicative Senescence
Aging

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STN1

References

PMID: 19854130 by Miyake Y., et al. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.

PMID: 19648609 by Wan M., et al. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.