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- Table of Contents
Facts about SUN domain-containing protein 2.
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the Link between the nuclear lamina and the cytoskeleton.
The nucleocytoplasmic interactions created by the LINC complex play an essential role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.Especially, SYNE2 and SUN2 build in arrays of transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow through actin- dependent nuclear movement. Required for interkinetic nuclear migration (INM) and necessary for nucleokinesis and centrosome- nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration.
Human | |
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Gene Name: | SUN2 |
Uniprot: | Q9UH99 |
Entrez: | 25777 |
Belongs to: |
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No superfamily |
FRIGG; KIAA0668; MGC133055; MGC133056; nuclear envelope protein; Protein unc-84 homolog B; Rab5-interacting protein; rab5IP; Sad1 and UNC84 domain containing 2; Sad1 unc-84 domain protein 2; Sad1/unc-84 protein-like 2; SUN domain-containing protein 2; unc-84 homolog B (C. elegans); unc-84 homolog B; UNC84B
Mass (kDA):
80.311 kDA
Human | |
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Location: | 22q13.1 |
Sequence: | 22; NC_000022.11 (38734727..38756014, complement) |
Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein.
This article will focus on Boster Bio's Anti–SUN2 Marker. We'll discuss the primary antibodies that are used in Boster Bio products, as well as common uses of the marker. We will also share the best practices to use the SUN2 mark. If you're a research scientist, you may also be interested in Boster Bio's Anti-Sun2 Marker.
Boster Bio's ELISA kit kits use primary antibodies that are derived from the human dynamin-1-like proteins, which is encoded in the DNM1L genes. This protein plays a role in the regulation the actin cell cytoskeleton. It's also found at the leading edge and membrane ruffles. A variety of diseases are linked to the human dynamin-1-like proteins, including Alzheimer's. It is also involved in the apoptosis and is a part of the programmed necrosis process. It is also implicated as a cause of Alzheimer's disease. This is a condition closely linked to mitochondrial fission defects and peroxisomal fission defect. Many RNAs are derived from the human dynamin-1 like protein gene.
Boster Bio's primary antibodies are highly specific and have a high affinity. The antibodies were validated for sensitivity and specificity through multiple platforms. Boster's antibodies have been rigorously tested by Western Blotting, ELISA and immunohistochemistry in order to ensure their quality. They can also be ordered online. Boster offers free shipping if you spend more than PS30. Boster offers more than just high-quality primary antibody products.
Primary antibodies are immunoglobulins, which bind specifically to a target antigen. Primary antibodies' quality is determined by the specificity of their interactions with targets. Good primary antibodies can detect the antigen and measure it. Boster Bio is the right choice if your research requires a high-quality, customized antigen. These antibodies can be used by researchers around the world in a variety if applications, including research and clinical trials.
The main components of the Boster Bio experiments and assays are primary antibodies. They are the active components of immunoassays that rely on antibodies' ability bind to antigens. Examples of immunoassays are Western Blotting and immunohistochemistry. Other applications include histopathology testing, proteomics, and other types of assays. Flow cytometry is another type of assay that measures the amounts of certain cell types of interest.
The SUN2 mark is a gene whose expression levels are highly dependent on the GST proteins. It has coil-coiled and transmembrane domains. The signal sequence is composed of amino acids 1-18. It is represented in vertical striped rectangles. The numbering system for KIAA0668 is used to label it. It also corresponds with GST/Sun residues 262-492.
The integral membrane component of the inner nucleus membrane of cells is the SUN2 protein. It is found in many tissues and organs of the body. It has potential anti-cancer properties, as it inhibits cell proliferation and migration and promotes apoptosis. The protein also plays a role in fibrogenesis, a common pathological feature of the final stage of cancer. Deficiency in SUN2 leads to DNA damage, which plays a crucial role in fibrosis.
PMID: 10818110 by Hoffenberg S., et al. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.
PMID: 17132086 by Wang Q., et al. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome.