This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Transcription elongation factor SPT5.
DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex.
Human | |
---|---|
Gene Name: | SUPT5H |
Uniprot: | O00267 |
Entrez: | 6829 |
Belongs to: |
---|
SPT5 family |
DRB sensitivity-inducing factor 160 kDa subunit; DRB sensitivity-inducing factor large subunit; DSIF large subunit; DSIF p160; FLJ34157; SPT5hSPT5; SPT5HTat-cotransactivator 1 protein; suppressor of Ty (S.cerevisiae) 5 homolog; suppressor of Ty 5 homolog (S. cerevisiae); Tat-CT1 protein; Tat-CT1; transcription elongation factor SPT5
Mass (kDA):
121 kDA
Human | |
---|---|
Location: | 19q13.2 |
Sequence: | 19; NC_000019.10 (39445546..39476670) |
Ubiquitously expressed.
Nucleus.
PMID: 8975720 by Chiang P.-W., et al. Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5.
PMID: 9199507 by Stachora A.A., et al. Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis.