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Polycomb protein SUZ12 Antibodies
AND SUZ12 ELISA kits, Polycomb protein SUZ12 Proteins
Many biological assays use antibodies to detect Polycomb protein SUZ12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Polycomb protein SUZ12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Polycomb protein SUZ12 antibodies...
Designing a Western blot for Polycomb protein SUZ12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SUZ12 Western Blot GuideDesigning an IHC experiment for Polycomb protein SUZ12? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SUZ12 IHC GuideSUZ12 Infographic by Boster Bio
All SUZ12 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00583-3
20μL, 40μL, 100μL, 200μL
Cat # M00583-3
20μL, 40μL, 100μL, 200μL
SUZ12 Overview
Facts about Polycomb protein SUZ12.
Polycomb protein SUZ12 (SUZ12)
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates'Lys-9' (H3K9me) and'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.
The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Gene Information
| Human | |
|---|---|
| Gene Name: | SUZ12 |
| Uniprot: | Q15022 |
| Entrez: | 23512 |
Family
| Belongs to: |
|---|
| VEFS (VRN2-EMF2-FIS2-SU(Z)12) family |
Alternative Names
ChET 9 protein; CHET9; CHET9polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; JJAZ1; JJAZ1Joined to JAZF1 protein; KIAA0160Suppressor of zeste 12 protein homolog; suppressor of zeste 12 homolog (Drosophila); SUZ12
Molecular Weight
Mass (kDA):
83.055 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (31937007..32001040) |
Tissue Specificity
Overexpressed in breast and colon cancer.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Neurofibromatosis 1
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Carcinoma
- Myeloid Leukemia
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Lymphoma
- Leukemia, Myelocytic, Acute
- Mammary Neoplasms
Interacting Proteins
- EED
- EZH2
- HDAC3
- HLX
Pathways
- Methylation
- Cell Differentiation
- Gene Silencing
- Histone Methylation
- Cell Proliferation
- Dna Methylation
- Histone Modification
- Pathogenesis
- Stem Cell Differentiation
- Chromatin Remodeling
- Localization
- Cell Growth
- Dna Hypermethylation
PTMs
- Methylation
- Acetylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SUZ12
bosterbio.com/bosterbio-gene-info-cards/SUZ12
References
PMID: 11371647 by Koontz J.I., et al. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.
PMID: 11564866 by Weinmann A.S., et al. Use of chromatin immunoprecipitation to clone novel E2F target promoters.