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- Table of Contents
Facts about Polycomb protein SUZ12.
The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
| Human | |
|---|---|
| Gene Name: | SUZ12 |
| Uniprot: | Q15022 |
| Entrez: | 23512 |

| Belongs to: |
|---|
| VEFS (VRN2-EMF2-FIS2-SU(Z)12) family |

ChET 9 protein; CHET9; CHET9polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; JJAZ1; JJAZ1Joined to JAZF1 protein; KIAA0160Suppressor of zeste 12 protein homolog; suppressor of zeste 12 homolog (Drosophila); SUZ12
Mass (kDA):
83.055 kDA

| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (31937007..32001040) |
Overexpressed in breast and colon cancer.
Nucleus.





PMID: 11371647 by Koontz J.I., et al. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.
PMID: 11564866 by Weinmann A.S., et al. Use of chromatin immunoprecipitation to clone novel E2F target promoters.