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- Table of Contents
SAMSN1 Antibodies
AND SAMSN1 ELISA kits, SAMSN1 Proteins
Many biological assays use antibodies to detect SAMSN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SAMSN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SAMSN1 antibodies...
Designing an IHC experiment for SAMSN1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SAMSN1 IHC GuideSAMSN1 Infographic by Boster Bio
All SAMSN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08977-2
100 μg/vial
Cat # A08977-2
100 μg/vial
SAMSN1 Overview
Facts about SAM domain-containing protein SAMSN-1.
SAM domain-containing protein SAMSN-1 (SAMSN1)
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro).
Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization.
Gene Information
| Human | |
|---|---|
| Gene Name: | SAMSN1 |
| Uniprot: | Q9NSI8 |
| Entrez: | 64092 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HACS1gene with homology to KIAA0790 protein10NASH1; Hematopoietic adaptor containing SH3 and SAM domains 1; SAM and SH3 domain containing 1; SAM and SH3 domain containing 2; SAM domain, SH3 domain and nuclear localisation signals, 1; SAM domain, SH3 domain and nuclear localization signals 1; SAM domain, SH3 domain and nuclear localization signals protein 1; SAM domain-containing protein SAMSN-1; SH3D6B; SH3-SAM adaptor protein
Molecular Weight
Mass (kDA):
41.708 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q11.2 |
| Sequence: | 21; NC_000021.9 (14485228..14583402, complement) |
Tissue Specificity
Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
Subcellular Localizations
Nucleus. Cytoplasm. Cell projection, ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity).
Diseases
- Malignant Neoplasms
- Multiple Myeloma
- Down Syndrome
- Myeloid Leukemia
- Leukemia
- Hematopoietic Neoplasms
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Carcinoma
- Ulcer
- Leukemia, Myelocytic, Acute
- Chronic Disease/disorder
- Neoplasms
Pathways
- Localization
- Cell Activation
- B Cell Activation
- Transport
- Cell Proliferation
- Cell Differentiation
- Vesicle-mediated Transport
- Rna Processing
- B Cell Proliferation
PTMs
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SAMSN1
bosterbio.com/bosterbio-gene-info-cards/SAMSN1
References
PMID: 11536050 by Claudio J.O., et al. HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells.
PMID: 11594764 by Uchida T., et al. Identification of Nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells.