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Sestrin-3 Antibodies

AND Sesn3 ELISA kits, Sestrin-3 Proteins

Many biological assays use antibodies to detect Sestrin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sestrin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sestrin-3 antibodies...

We validate the specificity of these antibodies to Sestrin-3 by testing them on tissues known to express Sesn3 positively and negatively. Browse below to find the Sesn3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Sesn3 Infographic by Boster Bio

Sesn3 protein infographic

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Anti-Sestrin-3 SESN3 Antibody

Western blot analysis of extracts of various cell lines, using SESN3 antibody at 1:1000 dilution

Western blot analysis of extracts of various cell lines, using SESN3 antibody at 1:1000 dilution

Human

WB

$405
Cat # A07894
100ul

Sesn3 Overview

Facts about Sestrin-3.

Sestrin-3 (Sesn3)

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25259925). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (PubMed:25377878).

This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). .

Gene Information

Mouse
Gene Name:	Sesn3
Uniprot:	Q9CYP7
Entrez:	75747

Gene Information

Family

Belongs to:

sestrin family

Family

Alternative Names

SEST3MGC29667; sestrin 3; sestrin-3

Molecular Weight

Mass (kDA):
57.021 kDA

Molecular Weight

Genomic Context


Mouse

Location:	9\|9 A1
Sequence:	9;

Tissue Specificity

Detected in liver and skeletal muscles.

Diseases

Malignant Neoplasms
Neoplasms
Insulin Resistance
Impaired Glucose Tolerance
Physiological Stress
Instabilities, Chromosomal
Ataxia
Endometrial Neoplasms
Endometrial Polyp
Chromosome Breakage
Situs Inversus
Uterine Cancer

Fatty Liver
Carcinoma, Endometrioid
Neuroblastoma
Situs Ambiguus
Genomic Instability
Atherosclerosis
Diabetes Mellitus

Disease

Pathways

Aging
Rna Interference
Methylation
Glucose Homeostasis
Regulation Of Glucose Homeostasis
Gene Silencing
Cell Cycle
Dna Repair

Energy Homeostasis
Autophagy

Pathways

PTMs

Phosphorylation

Methylation

Research Areas

Cell Cycle and Replication

Research Areas

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sesn3

References

PMID: 22958918 by Lee J.H., et al. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

PMID: 25259925 by Peng M., et al. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.