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- Table of Contents
SLC6A4 Antibodies
AND SLC6A4 ELISA kits, SLC6A4 Proteins
Many biological assays use antibodies to detect SLC6A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC6A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC6A4 antibodies...
Designing a Western blot for SLC6A4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC6A4 Western Blot GuideSLC6A4 Infographic by Boster Bio
All SLC6A4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, WB
$370
Cat # PB9438
100 μg/vial
Cat # PB9438
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # M00496
100 μl/vial
Cat # M00496
100 μl/vial
Human
$628
Cat # LS006532
20 µg, 100 µg
Cat # LS006532
20 µg, 100 µg
SLC6A4 Overview
Facts about Sodium-dependent serotonin transporter.
Sodium-dependent serotonin transporter (SLC6A4)
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules in the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems.
Terminates the action of serotonin and recycles it at a sodium-dependent method. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC6A4 |
| Uniprot: | P31645 |
| Entrez: | 6532 |
Family
| Belongs to: |
|---|
| sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family |
Alternative Names
5HT transporter; 5-HT Transporter; 5-HTT; 5HTTLPR; 5-HTTLPR; hSERT; HTT5-hydroxytryptamine transporter; Na+/Cl- dependent serotonin transporter; OCD1; Serotonin Transporter 1; SERT; SLC6A4; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4,5-HTTLPR; Solute carrier family 6 member 4,5HTT
Molecular Weight
Mass (kDA):
70.325 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (30194319..30235697, complement) |
Tissue Specificity
Expressed in platelets (at protein level).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell junction, synapse. Cell junction, focal adhesion. Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).
Diseases
- Depressive Disorder
- Major Depressive Disorder
- Anxiety Disorders
- Mental Disorders
- Mood Disorders
- Variable Number Tandem Repeat
- Bipolar Disorder
- Schizophrenia
- Stress, Psychological
- Cancer Patients And Suicide And Depression
- Depressive Symptom
Pathways
- Transport
- Pathogenesis
- Serotonin Uptake
- Serotonin Transport
- Innervation
- Localization
- Secretion
- Dopamine Uptake
- Cognition
- Aging
- Brain Development
- Methylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Reduction
- Glycosylation
- Biotinylation
- Demethylation
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC6A4
bosterbio.com/bosterbio-gene-info-cards/SLC6A4
References
PMID: 8452685 by Lesch K.P., et al. Isolation of a cDNA encoding the human brain serotonin transporter.
PMID: 7681602 by Ramamoorthy S., et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
2 Publications of Boster SLC6A4 Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41380-020-00978-y, Cocaine-induced locomotor stimulation involves autophagic degradation of the dop...
- PubMed ID: 31452710, Liu ZJ,Liu H,Wu C,Xue K.Effect of sepsis on the action potential and cardiac ser...
*More publications can be found for each product on its corresponding product page