SRGAP3 Antibodies

AND SRGAP3 ELISA kits, SRGAP3 Proteins

Many biological assays use antibodies to detect SRGAP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRGAP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRGAP3 antibodies...

We validate the specificity of these antibodies to SRGAP3 by testing them on tissues known to express SRGAP3 positively and negatively. Browse below to find the SRGAP3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for SRGAP3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SRGAP3 IHC Guide

SRGAP3 Infographic by Boster Bio

All SRGAP3 Products

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Product

Figures

Specificity

Applications

Price

Anti-SRGAP3 Antibody Picoband®

Western blot analysis of SRGAP3 using anti-SRGAP3 antibody (A06020-1)

IHC analysis of SRGAP3 using anti-SRGAP3 antibody (A06020-1)

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A06020-1
100 µg/vial

SRGAP3 (NM_014850) Human Over-expression Lysate

Human

$960
Cat # LS009901
20 µg, 100 µg

SRGAP3 (NM_014850) Human Recombinant Protein

Coomassie blue staining of purified SRGAP3 protein

$1062
Cat # PROTO43295
20 µg

SRGAP3 Overview

Facts about SLIT-ROBO Rho GTPase-activating protein 3.

SRGAP3 3D structure. Source: alphafold

SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)

GTPase-activating protein for RAC1 and Maybe Cdc42, but not for RhoA small GTPase.
May attenuate RAC1 signaling in neurons.

Gene Information

Human
Gene Name:	SRGAP3
Uniprot:	O43295
Entrez:	9901

Family

Belongs to:

No superfamily

Alternative Names

SLIT-ROBO Rho GTPase activating protein 2; SLIT-ROBO Rho GTPase activating protein 3

Molecular Weight

Mass (kDA):
124.504 kDA

Genomic Context


Human

Location:	3p25.3
Sequence:	3; NC_000003.12 (8980591..9363446, complement)

Tissue Specificity

Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.

Diseases

Haploinsufficiency
Congenital Heart Defects
Mental Disorders
Monosomy
Nervousness
Peripheral Nerve Injuries
Malignant Neoplasms
Neoplasms
Muscle Hypotonia
Heart Diseases
Pilocytic Astrocytoma
Hydrocephalus

Congenital Heart Disease
Neuroblastoma
Nerve Damage
Schizophrenia
Severe Mental Retardation
Tissue Adhesions
Autistic Disorder

Interacting Proteins

Amph
GRB2
HTT
Sh3gl1
Sh3gl2

Pathways

Axon Guidance
Localization
Brain Development
Neurogenesis
Regeneration
Long-term Memory
Transport
Cell Adhesion
Vesicle Transport
Cell Migration
Developmental Process

Prepulse Inhibition
Regulation Of Cytoskeleton
Social Behavior
Angiogenesis
Cell Morphogenesis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRGAP3

References

PMID: 12447388 by Soderling S.H., et al. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.

PMID: 12195014 by Endris V., et al. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation.