Serine/arginine repetitive matrix protein 4 (Srrm4)

Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its controlled target transcripts and promotes neural- specific exon inclusion in several genes that function in neural cell differentiation.

Required to encourage the inclusion of neural- specific exon 10 in nPTB/PTBP2, resulting in increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts.