SV2C Antibodies

AND SV2C ELISA kits, SV2C Proteins

Many biological assays use antibodies to detect SV2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SV2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SV2C antibodies...

We validate the specificity of these antibodies to SV2C by testing them on tissues known to express SV2C positively and negatively. Browse below to find the SV2C antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for SV2C? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SV2C IHC Guide

SV2C Infographic by Boster Bio

All SV2C Products

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Specificity

Applications

Price

Anti-SV2C Antibody Picoband®

Western blot analysis of SV2C using anti-SV2C antibody (A10958-1)

Flow Cytometry analysis of Jurkat cells using anti-SV2C antibody (A10958-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A10958-1
100 μg/vial

Anti-SV2C Antibody

Western Blot (WB) analysis of extracts from Jurkat cells, using SV2C Polyclonal antibody

Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain, antibody was diluted at 1:100

Human, Mouse, Rat

ELISA, IF, IHC, WB

$399
Cat # A10958
100μl

SV2C (NM_014979) Human Over-expression Lysate

Human

$960
Cat # LS022987
20 µg, 100 µg

SV2C Overview

Facts about Synaptic vesicle glycoprotein 2C.

SV2C 3D structure. Source: alphafold

Synaptic vesicle glycoprotein 2C (SV2C)

Plays a role in the management of regulated secretion in neural and endocrine cells, improving selectively low-frequency neurotransmission. Positively regulates vesicle fusion by keeping the readily releasable pool of secretory vesicles.

Gene Information

Human
Gene Name:	SV2C
Uniprot:	Q496J9
Entrez:	22987

Family

Belongs to:

major facilitator superfamily

Alternative Names

KIAA1054; MGC118874; MGC118875; MGC118876; MGC118877; SV2C; synaptic vesicle glycoprotein 2C; synaptic vesicle protein 2C

Molecular Weight

Mass (kDA):
82.342 kDA

Genomic Context


Human

Location:	5q13.3
Sequence:	5; NC_000005.10 (75847463..76353939)

Subcellular Localizations

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.

Diseases

Epilepsy
Night Blindness
Insulinoma
Malignant Neoplasm Of Breast
Neurotoxicity Syndromes
Blind Vision
Retinoblastoma
Malignant Neoplasms
Neoplasms
Globus Hystericus

Pheochromocytoma
Chimera Disorder
Epilepsy, Temporal Lobe
Congenital Stationary Night Blindness

Pathways

Exocytosis
Synaptic Transmission
Transport
Synaptic Vesicle Exocytosis
Cell Proliferation
Cell Development
Insulin Secretion
Localization
Cell Maturation
Regulation Of Synaptic Vesicle Exocytosis

Innervation
Rna Interference
Transdifferentiation
Secretion

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SV2C

References

PMID: 21483489 by Peng L., et al. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.

PMID: 27313224 by Mahrhold S., et al. Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.