Substance-K receptor Antibodies

AND TACR2 ELISA kits, Substance-K receptor Proteins

Many biological assays use antibodies to detect Substance-K receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Substance-K receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Substance-K receptor antibodies...

We validate the specificity of these antibodies to Substance-K receptor by testing them on tissues known to express TACR2 positively and negatively. Browse below to find the TACR2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TACR2 Infographic by Boster Bio

All TACR2 Products

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Specificity

Applications

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Anti-NK2R TACR2 Antibody

3 Q&As

Western blot analysis of lysates from NIH/3T3 and HT-29 cells, using NK2R Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$335
Cat # A30847
100ul

Anti-NK-2R (P340) TACR2 Antibody

Western blot (WB) analysis of NK-2R (P340) pAb at 1:500 dilution
Lane1:CT26 whole cell lysate(40ug)
Lane2:H9C2 whole cell lysate(40ug)
Lane3:Hela whole cell lysate(40ug)
Lane4:HCT116 whole cell lysate(40ug)

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A08100
100ul

Neurokinin A Receptor (TACR2) (NM_001057) Human Over-expression Lysate

Human

$628
Cat # LS006865
20 µg, 100 µg

TACR2 Overview

Facts about Substance-K receptor.

TACR2 3D structure. Source: alphafold

Substance-K receptor (TACR2)

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It's associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

The rank order of affinity of this receptor to tachykinins is: chemical K > neuromedin-K > substance P. .

Gene Information

Human
Gene Name:	TACR2
Uniprot:	P21452
Entrez:	6865

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

Neurokinin A Receptor; Neurokinin-2 Receptor; NK2R; NK2RNK-2 receptor; NKNAR; NKNARseven transmembrane helix receptor; SKR; SKRneurokinin 2 receptor; Substance K Receptor; substance-K receptor; TAC2R; TAC2Rsubstance K receptor; Tachykinin Receptor 2; tachykinin receptor 2NK-2R; TACR2

Molecular Weight

Mass (kDA):
44.442 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (69403903..69416918, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Cholangiocarcinoma
Urinary Incontinence
Chronic Constipation
Anxiety Disorders
Diverticulosis
Inflammatory Bowel Diseases
Irritable Bowel Syndrome
Constipation
Intestinal Diseases
Ulcer
Ulcerative Colitis

Malignant Neoplasms
Depressive Disorder
Crohn Disease
Inflammation
Alzheimer's Disease
Colorectal Cancer

Interacting Proteins

TAC1

Pathways

Sperm Motility
Localization
Secretion

PTMs

Disulfide bond
Glycoprotein

Lipoprotein
Palmitate

Research Areas

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TACR2

References

PMID: 2173708 by Gerard N.P., et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues.

PMID: 1659296 by Gerard N.P., et al. Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene.