TBC1D2 Antibodies

AND TBC1D2 ELISA kits, TBC1D2 Proteins

Many biological assays use antibodies to detect TBC1D2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBC1D2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBC1D2 antibodies...

We validate the specificity of these antibodies to TBC1D2 by testing them on tissues known to express TBC1D2 positively and negatively. Browse below to find the TBC1D2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TBC1D2 Infographic by Boster Bio

All TBC1D2 Products

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Anti-TBC1 domain family member 2A TBC1D2 Antibody

Western blot (WB) analysis of TBC1D2 polyclonal antibody at 1:500 dilution
Lane1:MCF-7 whole cell lysate
Lane2:sp2/0 whole cell lysate
Lane3:PC12 whole cell lysate

Human, Mouse, Rat

$405
Cat # A09458
100ul

TBC1D2 (NM_018421) Human Over-expression Lysate

Human

$960
Cat # LS055357
20 µg, 100 µg

TBC1D2 Overview

Facts about TBC1 domain family member 2A.

TBC1D2 3D structure. Source: alphafold

TBC1 domain family member 2A (TBC1D2)

Acts as GTPase-activating protein for RAB7A.
Signal effector behaving as a linker between RAC1 and RAB7A, resulting in RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.

Gene Information

Human
Gene Name:	TBC1D2
Uniprot:	Q9BYX2
Entrez:	55357

Family

Belongs to:

No superfamily

Alternative Names

Armus; FLJ10702; FLJ16244; FLJ42782; PARIS1member 2A; PP8997; TBC1 domain family, member 2

Molecular Weight

Mass (kDA):
105.414 kDA

Genomic Context


Human

Location:	9q22.33
Sequence:	9; NC_000009.12 (98198998..98255649, complement)

Tissue Specificity

Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level).

Subcellular Localizations

Cytoplasm. Cytoplasmic vesicle. Cell junction.

Diseases

Sclerosis
Multiple Sclerosis
Inflammatory Disorder
Autoimmune Reaction
Cns Disorder
Central Nervous System Inflammation
Nervousness

Tissue Adhesions
Chronic Inflammatory Disorder

Pathways

Cell Proliferation
Cell Cycle
Cell-cell Adhesion

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBC1D2

References

PMID: 11785977 by Zhou Y., et al. Serological cloning of PARIS-1: a new TBC domain-containing, immunogenic tumor antigen from a prostate cancer cell line.

PMID: 19077034 by Ishibashi K., et al. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.