TCEAL7 Antibodies

AND TCEAL7 ELISA kits, TCEAL7 Proteins

Many biological assays use antibodies to detect TCEAL7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCEAL7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCEAL7 antibodies...

We validate the specificity of these antibodies to TCEAL7 by testing them on tissues known to express TCEAL7 positively and negatively. Browse below to find the TCEAL7 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCEAL7 Infographic by Boster Bio

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Human TCEAL7 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9BRU2
Starting from 20ug

TCEAL7 Overview

Facts about Transcription elongation factor A protein-like 7.

TCEAL7 3D structure. Source: alphafold

Transcription elongation factor A protein-like 7 (TCEAL7)

Plays a role in the negative regulation of NF-kappa-B signaling at the intermediate level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression.

Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. .

Gene Information

Human
Gene Name:	TCEAL7
Uniprot:	Q9BRU2
Entrez:	56849

Family

Belongs to:

TFS-II family

Alternative Names

transcription elongation factor A protein-like 7; MPMGp800C04260Q003; transcription elongation factor A (SII)-like 7

Molecular Weight

Mass (kDA):
12.324 kDA

Genomic Context


Human

Location:	Xq22.2
Sequence:	X; NC_000023.11 (103330186..103332326)

Tissue Specificity

Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Neoplasms
Epithelial Ovarian Cancer
Cell Transformation, Neoplastic
Tumor Progression
Muscular Dystrophy, Duchenne
Tissue Adhesions

Dystrophy
Metaplastic Cell Transformation
Hyperplasia
Muscular Dystrophy

Pathways

Senescence
Methylation
Replicative Senescence
Regeneration
Cell Death
Telomere Maintenance
Cell Growth

Demethylation

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCEAL7

References

PMID: 18806825 by Chien J., et al. A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation.

PMID: 20454512 by Lafferty-Whyte K., et al. TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.