Transcription factor 4 Antibodies

AND TCF4 ELISA kits, Transcription factor 4 Proteins

Many biological assays use antibodies to detect Transcription factor 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor 4 antibodies...

We validate the specificity of these antibodies to Transcription factor 4 by testing them on tissues known to express TCF4 positively and negatively. Browse below to find the TCF4 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Transcription factor 4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the TCF4 Western Blot Guide

TCF4 Infographic by Boster Bio

All TCF4 Products

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Product

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Specificity

Applications

Price

Anti-TCF4 Antibody Picoband®

1 Citations

Western blot analysis of TCF4 using anti-TCF4 antibody (A00674-2)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A00674-2
100 μg/vial

Anti-TCF4 Rabbit Monoclonal Antibody

Western blot analysis of TCF4 expression in SH-SY5Y cell lysate

Human

Flow Cytometry, IHC, WB

$370
Cat # M00674
100 μl/vial

Anti-TCF4/TCF7L2 Antibody

1 Citations

Human, Mouse, Rat

ELISA, IP, IHC, WB

$370
Cat # A00431-2
100 μl/vial

TCF4 (NM_001083962) Human Over-expression Lysate

TCF4 Human Over-expression Lysates NM_001083962

Human

$960
Cat # LS006925
20 µg, 100 µg

Anti-TCF-4/12 (S616) Antibody

Western blot (WB) analysis of TCF-4/12 (S616) pAb at 1:500 dilution
Lane1:SGC7901 whole cell lysate(20ug)
Lane2:HepG2 whole cell lysate(40ug)
Lane3:Jurkat whole cell lysate(40ug)
Lane4:A549 whole cell lysate(40ug)
Lane5:PMVEC whole cell lysate(40ug)
Lane6:AML-12 whole cell lysate(40ug)

Human, Mouse, Rat

IHC, WB

$405
Cat # A00674S616
100ul

TCF4 Overview

Facts about Transcription factor 4.

TCF4 3D structure. Source: alphafold

Transcription factor 4 (TCF4)

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation.

Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).

Gene Information

Human
Gene Name:	TCF4
Uniprot:	P15884
Entrez:	6925

Family

Belongs to:

No superfamily

Alternative Names

BHLHB19; bHLHb19E2-2; Class B basic helix-loop-helix protein 19; Immunoglobulin transcription factor 2; ITF-2; ITF2PTHS; MGC149724; SEF-2; SEF2-1; SEF2-1A; SEF2-1B; SEF2MGC149723; SL3-3 enhancer factor 2; TCF-4; transcription factor 4

Molecular Weight

Mass (kDA):
71.308 kDA

Genomic Context


Human

Location:	18q21.2
Sequence:	18; NC_000018.10 (55222185..55635957, complement)

Tissue Specificity

Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Colorectal Cancer
Cell Transformation, Neoplastic
Colorectal Neoplasms
Malignant Tumor Of Colon
Colonic Neoplasms
Carcinogenesis
Neoplasm Metastasis
Adenocarcinoma
Adenomatous Polyposis Coli

Polyposis
Cell Invasion
Adenoma
Schizophrenia
Tissue Adhesions
Neoplasm Invasiveness

Pathways

Cell Proliferation
Cell Growth
Cell Cycle
Localization
Cell Differentiation
Pathogenesis
Rna Interference
Cell Adhesion
Methylation
Brain Development
Regeneration
Cell Development
Cell Death

Cell-cell Adhesion
Cell Migration
Epithelial Cell Proliferation
Transdifferentiation
Secretion
Transport
Cell Cycle Arrest

PTMs

Phosphorylation
Methylation
Acetylation
Dephosphorylation
Amidation
Nitration

Glycosylation
Cleavage
Sumoylation
Nitrosylation
Ubiquitination
Reduction

Farnesylation

Research Areas

Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCF4

References

PMID: 1681116 by Corneliussen B., et al. Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.

PMID: 21789225 by Sepp M., et al. Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.