JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Transcobalamin-1 Antibodies

AND TCN1 ELISA kits, Transcobalamin-1 Proteins

Many biological assays use antibodies to detect Transcobalamin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcobalamin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcobalamin-1 antibodies...

We validate the specificity of these antibodies to Transcobalamin-1 by testing them on tissues known to express TCN1 positively and negatively. Browse below to find the TCN1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: TCOF1

TCN1 Infographic by Boster Bio

TCN1 protein infographic

All TCN1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Transcobalamin-1 TCN1 Antibody

Western blot analysis of extracts of various cell lines, using TCN1 antibody at 1:1000 dilution

Western blot analysis of extracts of various cell lines, using TCN1 antibody at 1:1000 dilution

Human, Mouse, Rat

WB

$405
Cat # A10041
100ul

TCN1 (NM_001062) Human Over-expression Lysate

TCN1 Human Over-expression Lysates NM_001062

TCN1 Human Over-expression Lysates NM_001062

Human

$960
Cat # LS006947
20 µg, 100 µg

TCN1 Overview

Facts about Transcobalamin-1.

TCN1 3D structure

TCN1 3D structure. Source: alphafold

Transcobalamin-1 (TCN1)

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. .

Gene Information

Human
Gene Name:	TCN1
Uniprot:	P20061
Entrez:	6947

Gene Information

Family

Belongs to:

eukaryotic cobalamin transport proteins family

Family

Alternative Names

haptocorin; TC I; TC-1; TC1haptocorrin; TCItranscobalamin-1; transcobalamin I (vitamin B12 binding protein, R binder family); Transcobalamin I

Molecular Weight

Mass (kDA):
48.207 kDA

Molecular Weight

Genomic Context


Human

Location:	11q12.1
Sequence:	11; NC_000011.10 (59852808..59866487, complement)

Tissue Specificity

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.

Subcellular Localizations

Secreted.

Subcellular Localization

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Malignant Neoplasms
Neoplasms
Anemia
Stomach Neoplasms
Anemia, Pernicious
Hereditary Diseases
Malignant Paraganglionic Neoplasm
Cardiovascular Diseases
Vitamin B 12 Deficiency
Malignant Neoplasm Of Stomach
Anemia, Megaloblastic

Hyperplasia
Mastitis-metritis-agalactia Syndrome
Confusion
Carcinoma
Feline Urological Syndrome
Mammary Neoplasms
Lymphoma

Disease

Pathways

Transport
Granulocyte Differentiation
Cell Proliferation
Aging
Dna Methylation
Response To Statin
Localization
Cell Cycle Arrest
Inflammatory Response
Methylation

Cell Cycle
Root Development
Rna Interference
Autophagy

Pathways

PTMs

Disulfide bond

Glycoprotein

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCN1

References

PMID: 2777761 by Johnston J., et al. Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein.

PMID: 23846701 by Furger E., et al. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.