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- Table of Contents
Treacle protein Antibodies
AND TCOF1 ELISA kits, Treacle protein Proteins
Many biological assays use antibodies to detect Treacle protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Treacle protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Treacle protein antibodies...
Designing an IHC experiment for Treacle protein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TCOF1 IHC GuideTCOF1 Infographic by Boster Bio
All TCOF1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02653-2
100 μg/vial
Cat # A02653-2
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1796
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1796
1 kit, containing one 96-well plate and all necessary reagents
Human
$628
Cat # LS006949
20 µg, 100 µg
Cat # LS006949
20 µg, 100 µg
TCOF1 Overview
Facts about Treacle protein.
Treacle protein (TCOF1)
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favour of neural crest specification (PubMed:26399832).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | TCOF1 |
| Uniprot: | Q13428 |
| Entrez: | 6949 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
MFD1; nucleolar trafficking phosphoprotein; TCS1; Treacher Collins syndrome protein; Treacher Collins-Franceschetti syndrome 1; treacle protein; treacle
Molecular Weight
Mass (kDA):
152.106 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q32-q33.1 |
| Sequence: | 5; NC_000005.10 (150357639..150400308) |
Subcellular Localizations
Nucleus, nucleolus.
Diseases
- Mandibulofacial Dysostosis
- Haploinsufficiency
- Cleft Palate
- Conductive Hearing Loss
- Hypoplasia
- Congenital Abnormality
- Dysostoses
- Micrognathism
- Crest Syndrome
- Complete Hearing Loss
- Congenital Small Ears
- Craniofacial Abnormalities
- Congenital Ocular Coloboma (disorder)
Interacting Proteins
- ARRB1
- ARRB2
- NBN
Pathways
- Localization
- Pathogenesis
- Ribosome Biogenesis
- Translation
- Mitosis
- Cell Death
- Cell Cycle
- Transport
- Cell Adhesion
- Cell Migration
- Peristalsis
- Neurogenesis
- Neuron Differentiation
PTMs
- Phosphorylation
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCOF1
bosterbio.com/bosterbio-gene-info-cards/TCOF1
References
PMID: 8563749 by Dixon J., et al. Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome.
PMID: 9074926 by Dixon J., et al. Identification of the complete coding sequence and genomic organization of the Treacher Collins syndrome gene.