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- Table of Contents
Facts about Tudor domain-containing protein 1.
Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring that the entry of correct transcripts into the standard piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway.
Human | |
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Gene Name: | TDRD1 |
Uniprot: | Q9BXT4 |
Entrez: | 56165 |
Belongs to: |
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TDRD1 family |
CT41.1; CT41.1Cancer/testis antigen 41.1; FLJ21082; TDRD1; tudor domain containing 1; tudor domain containing protein 1; tudor domain-containing protein 1
Mass (kDA):
132.024 kDA
Human | |
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Location: | 10q25.3 |
Sequence: | 10; NC_000010.11 (114174442..114232669) |
Testis and ovary specific. Also expressed in several cancers.
Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).
PMID: 11279525 by Wang P.J., et al. An abundance of X-linked genes expressed in spermatogonia.
PMID: 12704671 by Loriot A., et al. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia.