Telomere length regulation protein TEL2 homolog (TELO2)

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.

The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Along with the TTT complex and HSP90 may participate in the correct folding of newly synthesized PIKKs.