TENT4B Antibodies

AND TENT4B ELISA kits, TENT4B Proteins

Many biological assays use antibodies to detect TENT4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TENT4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TENT4B antibodies...

We validate the specificity of these antibodies to TENT4B by testing them on tissues known to express TENT4B positively and negatively. Browse below to find the TENT4B antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TENT4B Infographic by Boster Bio

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TENT4B Overview

Facts about Terminal nucleotidyltransferase 4B.

TENT4B 3D structure. Source: alphafold

Terminal nucleotidyltransferase 4B (TENT4B)

Catalytic subunit of a TRAMP-like complex that has a poly(A) RNA polymerase activity and is involved in a post- transcriptional excellent control mechanism. Polyadenylation with short oligo(A) tails is needed for the degradative action of the exosome on several of its nuclear RNA substrates.

Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716).

Gene Information

Human
Gene Name:	TENT4B
Uniprot:	Q8NDF8
Entrez:	64282

Family

Belongs to:

DNA polymerase type-B-like family

Alternative Names

Terminal nucleotidyltransferase 4B

Molecular Weight

Mass (kDA):
63.267 kDA

Genomic Context


Human

Location:	16q12.1
Sequence:	16; NC_000016.10 (50152911..50235310)

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Cytoplasm. Predominantly expressed in the cytoplasm (PubMed:18172165).

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TENT4B

References

PMID: 10066793 by Walowsky C., et al. The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin.

PMID: 18172165 by Mullen T.E., et al. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.