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- Table of Contents
TFAP2C Antibodies
AND TFAP2C ELISA kits, TFAP2C Proteins
Many biological assays use antibodies to detect TFAP2C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TFAP2C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TFAP2C antibodies...
Designing a Western blot for TFAP2C? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TFAP2C Western Blot GuideDesigning an IHC experiment for TFAP2C? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TFAP2C IHC GuideTFAP2C Infographic by Boster Bio
All TFAP2C Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, IF, IHC, ICC, WB
$370
Cat # A01558-2
100 μg/vial
Cat # A01558-2
100 μg/vial
TFAP2C Overview
Facts about Transcription factor AP-2 gamma.
Transcription factor AP-2 gamma (TFAP2C)
Sequence-specific DNA-binding protein which interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development.
They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Gene Information
| Human | |
|---|---|
| Gene Name: | TFAP2C |
| Uniprot: | Q92754 |
| Entrez: | 7022 |
Family
| Belongs to: |
|---|
| AP-2 family |
Alternative Names
Activating enhancer-binding protein 2 gamma; AP2 gamma; AP-2 gamma; AP2-GAMMA; ERF1; estrogen receptor factor 1; hAP-2g; TFAP2C; TFAP2G; transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma); transcription factor AP-2 gamma; Transcription factor ERF-1
Molecular Weight
Mass (kDA):
49.177 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.31 |
| Sequence: | 20; NC_000020.11 (56629306..56639283) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Carcinoma In Situ
- Crest Syndrome
- Testicular Neoplasms
- Neoplasms, Germ Cell And Embryonal
- Choriocarcinoma
- Embryonal Carcinoma
Interacting Proteins
- CITED2
- UBE2I
Pathways
- Methylation
- Cell Differentiation
- Oncogenesis
- Gastrulation
- Dna Methylation
- Cell Growth
- Pathogenesis
- Spermatogenesis
- Cell Cycle
- Cell Development
- Localization
- Germ Cell Development
- Transport
PTMs
- Methylation
- Cleavage
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TFAP2C
bosterbio.com/bosterbio-gene-info-cards/TFAP2C
References
PMID: 8661133 by Williamson J.A., et al. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.
PMID: 9113991 by McPherson L.A., et al. Identification of ERF-1 as a member of the AP2 transcription factor family.