Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Functions as a molecular adapter coordinating multiple protein-protein interactions in the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membranes and regulates the Wnt and TGFB signaling pathways.

May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity.