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- Table of Contents
Thrombomodulin Antibodies
AND THBD ELISA kits, Thrombomodulin Proteins
Many biological assays use antibodies to detect Thrombomodulin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Thrombomodulin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Thrombomodulin antibodies...
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THBD Infographic by Boster Bio
All THBD Products
Product
Figures
Specificity
Applications
Price
Human Thrombomodulin ELISA Kit PicoKine®
4 Citations 10 Q&As
Human
ELISA
$499
Cat # EK0917
96 wells/kit, with removable strips.
Cat # EK0917
96 wells/kit, with removable strips.
Mouse Thrombomodulin ELISA Kit PicoKine®
1 Citations 9 Q&As
Mouse
ELISA
$499
Cat # EK1119
96 wells/kit, with removable strips.
Cat # EK1119
96 wells/kit, with removable strips.
Monkey
ELISA
$499
Cat # EK0917-PR
96 wells/kit, with removable strips.
Cat # EK0917-PR
96 wells/kit, with removable strips.
Anti-Thrombomodulin THBD Rabbit Monoclonal Antibody
1 Citations 1 Q&As
Human
IP, IF, IHC, ICC, WB
$370
Cat # M01325-1
100 μl
Cat # M01325-1
100 μl
Human
ELISA
$499
Cat # FEK0917
96 wells/kit, with removable strips.
Cat # FEK0917
96 wells/kit, with removable strips.
Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M01325-2
100 μl/vial
Cat # M01325-2
100 μl/vial
Human, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A01325-3
100 µg/vial
Cat # A01325-3
100 µg/vial
THBD Overview
Facts about Thrombomodulin.
Thrombomodulin (THBD)
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca).
Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. .
Gene Information
| Human | |
|---|---|
| Gene Name: | THBD |
| Uniprot: | P07204 |
| Entrez: | 7056 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BDCA3; BDCA-3; CD141 antigen; CD141; Fetomodulin; THBD; THRM; Thrombomodulin; TM
Molecular Weight
Mass (kDA):
60.329 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p11.21 |
| Sequence: | 20; NC_000020.11 (23045633..23049672, complement) |
Tissue Specificity
Endothelial cells are unique in synthesizing thrombomodulin.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Inflammation
- Thrombosis
- Neoplasms
- Disseminated Intravascular Coagulation
- Tissue Adhesions
- Hemolytic-uremic Syndrome
- Von Willebrand Disease
- Atherosclerosis
- Coronary Artery Disease
- Carcinoma
- Uremia Syndrome
- Cerebrovascular Accident
Interacting Proteins
- F2
Pathways
- Coagulation
- Pathogenesis
- Methylation
- Blood Coagulation
- Dna Methylation
- Inflammatory Response
- Hemostasis
- Angiogenesis
- Fibrinolysis
- Cell Activation
- Complement Activation
- Transdifferentiation
- Cell Proliferation
PTMs
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/THBD
bosterbio.com/bosterbio-gene-info-cards/THBD
References
PMID: 2820710 by Suzuki K., et al. Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.
PMID: 2822087 by Wen D., et al. Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene.
4 Publications of Boster Thrombomodulin Antibodies & ELISA Kits
- PubMed ID: 10.1152/japplphysiol.00477.2019, The effects of moderate and high-intensity exercise on circulating markers of en...
- PubMed ID: 10.1111/jcmm.14474, miR‐499 released during myocardial infarction causes endothelial injury by tar...
- PubMed ID: 10.1016/j.wem.2017.05.002, Blood Hemostatic Changes During an Ultraendurance Road Cycling Event in a Hot En...
- PubMed ID: 28739377, Kupchak, B.R., Kazman, J.B., Vingren, J.L., Levitt, D.E., Lee, E.C., Williamson,...
*More publications can be found for each product on its corresponding product page