THO complex subunit 2 Antibodies

AND THOC2 ELISA kits, THO complex subunit 2 Proteins

Many biological assays use antibodies to detect THO complex subunit 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with THO complex subunit 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop THO complex subunit 2 antibodies...

We validate the specificity of these antibodies to THO complex subunit 2 by testing them on tissues known to express THOC2 positively and negatively. Browse below to find the THOC2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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THOC2 Infographic by Boster Bio

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Anti-THOC2 Antibody

Human

IF, ICC, WB

$370
Cat # A08443-1
100 μl/vial

THOC2 Overview

Facts about THO complex subunit 2.

THOC2 3D structure. Source: alphafold

THO complex subunit 2 (THOC2)

Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex that's thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.

TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and can be recruited in a splicing- and cap-dependent way to a region near the 5' end of the mRNA where it functions in mRNA export into the cytoplasm through the TAP/NFX1 pathway. The TREX complex is vital for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Gene Information

Human
Gene Name:	THOC2
Uniprot:	Q8NI27
Entrez:	57187

Family

Belongs to:

THOC2 family

Alternative Names

CXorf3; dJ506G2.1; hTREX120; THO complex 2; THO complex subunit 2

Molecular Weight

Mass (kDA):
182.775 kDA

Genomic Context


Human

Location:	Xq25
Sequence:	X; NC_000023.11 (123600563..123733054, complement)

Tissue Specificity

Expressed in the hippocampus and the cerebral cortex.

Subcellular Localizations

Nucleus. Nucleus speckle.

Pathways

Cell Growth
Nuclear Export

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/THOC2

References

PMID: 11979277 by Straesser K., et al. TREX is a conserved complex coupling transcription with messenger RNA export.

PMID: 15833825 by Guo S., et al. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.