TIFA Antibodies

AND TIFA ELISA kits, TIFA Proteins

Many biological assays use antibodies to detect TIFA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIFA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIFA antibodies...

We validate the specificity of these antibodies to TIFA by testing them on tissues known to express TIFA positively and negatively. Browse below to find the TIFA antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TIFA Infographic by Boster Bio

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Human TIFA Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ96CG3
Starting from 10ug

TIFA Overview

Facts about TRAF-interacting protein with FHA domain-containing protein A.

TIFA 3D structure. Source: alphafold

TRAF-interacting protein with FHA domain-containing protein A (TIFA)

Adapter protein that mediates the IRAK1 and TRAF6 interaction after IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which contributes to the activation of TAK1 and IKK through a proteasome-independent mechanism.

Gene Information

Human
Gene Name:	TIFA
Uniprot:	Q96CG3
Entrez:	92610

Family

Belongs to:

TIFA family

Alternative Names

TRAF-interacting protein with FHA domain-containing protein A

Molecular Weight

Mass (kDA):
21.445 kDA

Genomic Context


Human

Location:	4q25
Sequence:	4; NC_000004.12 (112274537..112285904, complement)

Subcellular Localizations

Cytoplasm. Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation.

Interacting Proteins

AP1M1
ARHGEF39
DVL2
LNX1
NXF1

RPL9
SDCBP
SDCBP2
TNFAIP8
TRAF2

TRAF6
TXN2

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIFA

References

PMID: 12566447 by Takatsuna H., et al. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.

PMID: 12761501 by Matsuda A., et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.