TLE2 Antibodies

AND TLE2 ELISA kits, TLE2 Proteins

Many biological assays use antibodies to detect TLE2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TLE2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TLE2 antibodies...

We validate the specificity of these antibodies to TLE2 by testing them on tissues known to express TLE2 positively and negatively. Browse below to find the TLE2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for TLE2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the TLE2 IHC Guide

TLE2 Infographic by Boster Bio

All TLE2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TLE2 Antibody

Western blot analysis of lysates from LOVO cells, using TLE2 Antibody

Western blot analysis of the lysates from HT-29 cells using TLE2 antibody

Immunohistochemical analysis of paraffin-embedded human tonsil

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A10582-1
100ul

TLE2 (NM_003260) Human Over-expression Lysate

TLE2 Human Over-expression Lysates NM_001144762

Human

$628
Cat # LS007089
20 µg, 100 µg

TLE2 Overview

Facts about Transducin-like enhancer protein 2.

TLE2 3D structure. Source: alphafold

Transducin-like enhancer protein 2 (TLE2)

Transcriptional corepressor that binds to a variety of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling.

The impacts of full-length TLE family members might be modulated by association with dominant-negative AES (By similarity). .

Gene Information

Human
Gene Name:	TLE2
Uniprot:	Q04725
Entrez:	7089

Family

Belongs to:

WD repeat Groucho/TLE family

Alternative Names

enhancer of split groucho 2; ESG; ESG2; ESG2Enhancer of split groucho-like protein 2; FLJ41188; GRG2; TLE2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2

Molecular Weight

Mass (kDA):
79.841 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (2997638..3047635, complement)

Tissue Specificity

In all tissues examined, mostly in heart, brain, and muscle.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Adenoma
Sarcoma
Pituitary Diseases
Pituitary Neoplasms
Malignant Paraganglionic Neoplasm
Idiopathic Hypereosinophilic Syndrome
Pituitary Adenoma
Chromosomal Translocation
Leukemia, Myelocytic, Acute
Metaplasia

Meningeal Disorder
Embryonal Carcinoma
Intracranial Neoplasm
Malignant Neoplasm Of Breast
Grade I Astrocytoma
Conductive Hearing Loss
Neoplasm Invasiveness

Interacting Proteins

DDB1

Pathways

Neurogenesis
Notch Signaling Pathway
Segmentation
Pathogenesis
Cell Proliferation
Pancreas Development
Osteoblast Differentiation
Proteolysis
Sex Determination
Localization
Cell Maturation
Methylation
Drug Resistance

Endocrine Pancreas Development
Reverse Transcription
Ear Development
Viral Latency
Cell Growth
Bone Development
Histone Methylation

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLE2

References

PMID: 1303260 by Stifani S., et al. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PMID: 9874198 by Grbavec D., et al. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.