Bax inhibitor 1 Antibodies

AND TMBIM6 ELISA kits, Bax inhibitor 1 Proteins

Many biological assays use antibodies to detect Bax inhibitor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bax inhibitor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bax inhibitor 1 antibodies...

We validate the specificity of these antibodies to Bax inhibitor 1 by testing them on tissues known to express TMBIM6 positively and negatively. Browse below to find the TMBIM6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Bax inhibitor 1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the TMBIM6 IHC Guide

TMBIM6 Infographic by Boster Bio

All TMBIM6 Products

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Applications

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Anti-BI-1/TMBIM6 Antibody Picoband®

Western blot analysis of BI-1/TMBIM6 using anti-BI-1/TMBIM6 antibody (A05462)

IHC analysis of BI-1/TMBIM6 using anti-BI-1/TMBIM6 antibody (A05462)

Human

IF, IHC, ICC, WB

$370
Cat # A05462
100 μg/vial

Bax inhibitor 1 (TMBIM6) (NM_003217) Human Over-expression Lysate

Human

$628
Cat # LS007009
20 µg, 100 µg

TMBIM6 Overview

Facts about Bax inhibitor 1.

TMBIM6 3D structure. Source: alphafold

Bax inhibitor 1 (TMBIM6)

Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086).

Modulates ER calcium homeostasis by acting as a calcium-leak station (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient depletion, and reduces cell survival during puberty (By similarity).

Gene Information

Human
Gene Name:	TMBIM6
Uniprot:	P55061
Entrez:	7009

Family

Belongs to:

BI1 family

Alternative Names

BAXI1; BI1; BI-1Transmembrane BAX inhibitor motif-containing protein 6; TEGTbax inhibitor 1; testis enhanced gene transcript; Testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif containing 6

Molecular Weight

Mass (kDA):
26.538 kDA

Genomic Context


Human

Location:	12q13.12
Sequence:	12; NC_000012.12 (49741557..49764934)

Tissue Specificity

Highly abundant in testis.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Endoplasmic Reticulum Stress
Carcinoma
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Fibrosarcoma
Physiological Stress
Cerebrovascular Accident
Mammary Neoplasms
Adenocarcinoma
Ischemia

Malignant Paraganglionic Neoplasm
Arterial Occlusion
Diabetes Mellitus
Cancer Of Nasopharynx
Liver Regeneration Disorder
Cell Transformation, Neoplastic
Nasopharyngeal Neoplasms

Interacting Proteins

ODF4
PSEN1
RNF185

Pathways

Cell Death
Programmed Cell Death
Rna Interference
Liver Regeneration
Cell Proliferation
Localization
Protein Oligomerization
Regeneration
Cell Growth
Tissue Homeostasis
Autophagy
Cell Adhesion
Hyperphosphorylation

Cell Migration
Gluconeogenesis
Hypersensitivity
Hepatocyte Proliferation
Regulation Of Programmed Cell Death
Spermatogenesis
Sensitization

PTMs

Phosphorylation
Cleavage

Carboxylation
Dephosphorylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMBIM6

References

PMID: 8530040 by Walter L., et al. Identification of a novel conserved human gene, TEGT.

PMID: 9660918 by Xu Q., et al. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.