TMEM131L Antibodies

AND TMEM131L ELISA kits, TMEM131L Proteins

Many biological assays use antibodies to detect TMEM131L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TMEM131L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TMEM131L antibodies...

We validate the specificity of these antibodies to TMEM131L by testing them on tissues known to express TMEM131L positively and negatively. Browse below to find the TMEM131L antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMEM131L Infographic by Boster Bio

All TMEM131L Products

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TMEM131L (KIAA0922) (NM_015196) Human Over-expression Lysate

Human

$960
Cat # LS023240
100 µg

TMEM131L Overview

Facts about Transmembrane protein 131-like.

TMEM131L 3D structure. Source: alphafold

Transmembrane protein 131-like (TMEM131L)

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Gene Information

Human
Gene Name:	TMEM131L
Uniprot:	A2VDJ0
Entrez:	23240

Family

Belongs to:

TMEM131 family

Alternative Names

Transmembrane protein 131-like

Molecular Weight

Mass (kDA):
179.339 kDA

Genomic Context


Human

Location:	4q31.3
Sequence:	4; NC_000004.12 (153466346..153637608)

Tissue Specificity

Expressed in thymocytes.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cytoplasm. During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones.; [Isoform 1]: Endoplasmic reticulum. Transmembrane localization is essential for Wnt signaling inhibition.; [Isoform 5]: Cytoplasm. Scattered throughout the cytoplasm in small-sized punctate structures.

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEM131L

References

PMID: 23690469 by Maharzi N., et al. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.