TMLHE Antibodies

AND TMLHE ELISA kits, TMLHE Proteins

Many biological assays use antibodies to detect TMLHE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TMLHE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TMLHE antibodies...

We validate the specificity of these antibodies to TMLHE by testing them on tissues known to express TMLHE positively and negatively. Browse below to find the TMLHE antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMLHE Infographic by Boster Bio

All TMLHE Products

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Product

Figures

Specificity

Applications

Price

TMLHE (NM_018196) Human Over-expression Lysate

Human

$960
Cat # LS055217
20 µg, 100 µg

Anti-TMLHE Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A09060-1
100 μl/vial

TMLHE Overview

Facts about Trimethyllysine dioxygenase, mitochondrial.

TMLHE 3D structure. Source: alphafold

Trimethyllysine dioxygenase, mitochondrial (TMLHE)

Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). .

Gene Information

Human
Gene Name:	TMLHE
Uniprot:	Q9NVH6
Entrez:	55217

Family

Belongs to:

gamma-BBH/TMLD family

Alternative Names

BBOX2TML-alpha-ketoglutarate dioxygenase; butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetainehydroxylase) 2; EC 1.14.11.8; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; Epsilon-trimethyllysine hydroxylase; FLJ10727; TML dioxygenase; TMLD; TMLHTML hydroxylase; trimethyllysine dioxygenase, mitochondrial; trimethyllysine hydroxylase, epsilon; XAP130

Molecular Weight

Mass (kDA):
49.518 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (155489011..155612952, complement)

Tissue Specificity

All isoforms, but isoform 8, are widely expressed in adult and fetal tissues. Isoform 8 is restricted to heart and skeletal muscle.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Autistic Disorder
Dysequilibrium Syndrome
Hereditary Diseases
Inborn Errors Of Metabolism
Blood Coagulation Disorders
Genetic Diseases, X-linked
Myopia
Hemophilia A

Autism Spectrum Disorders
Visual Impairment

Pathways

Transport
Lactation
Fatty Acid Oxidation

PTMs

Acetylation

Research Areas

DNA Repair
Mismatch Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMLHE

References

PMID: 11431483 by Vaz F.M., et al. Molecular and biochemical characterization of rat epsilon-N- trimethyllysine hydroxylase, the first enzyme of carnitine biosynthesis.

PMID: 15754339 by Monfregola J., et al. Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting.