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- Table of Contents
Facts about Trophoblast glycoprotein.
Human | |
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Gene Name: | TPBG |
Uniprot: | Q13641 |
Entrez: | 7162 |
Belongs to: |
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No superfamily |
5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4; 5T4AG; 5T4-AG; 5T4M6P1,5T4 oncofetal antigen; M6P1; TPBG; trophoblast glycoprotein
Mass (kDA):
46.032 kDA
Human | |
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Location: | 6q14.1 |
Sequence: | 6; NC_000006.12 (82362983..82367420) |
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Cell membrane; Single-pass type I membrane protein.
PMID: 8132670 by Myers K.A., et al. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats.
PMID: 12481437 by Mulryan K., et al. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors.