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- Table of Contents
Trophoblast glycoprotein Antibodies
AND TPBG ELISA kits, Trophoblast glycoprotein Proteins
Many biological assays use antibodies to detect Trophoblast glycoprotein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Trophoblast glycoprotein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Trophoblast glycoprotein antibodies...
Designing an IHC experiment for Trophoblast glycoprotein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TPBG IHC GuideTPBG Infographic by Boster Bio
All TPBG Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07442-2
100 μg
Cat # M07442-2
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07442-5
100 μg
Cat # M07442-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07442-4
100 μg
Cat # M07442-4
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07442-3
100 μg
Cat # M07442-3
100 μg
TPBG Overview
Facts about Trophoblast glycoprotein.
Trophoblast glycoprotein (TPBG)
May function as an inhibitor of Wnt/beta-catenin indicating by indirectly interacting with LRP6 and blocking Wnt3a- reliant LRP6 internalization. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TPBG |
| Uniprot: | Q13641 |
| Entrez: | 7162 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4; 5T4AG; 5T4-AG; 5T4M6P1,5T4 oncofetal antigen; M6P1; TPBG; trophoblast glycoprotein
Molecular Weight
Mass (kDA):
46.032 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q14.1 |
| Sequence: | 6; NC_000006.12 (82362983..82367420) |
Tissue Specificity
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasms
- Glomerulonephritis, Membranoproliferative
- Adenocarcinoma
- Vaccinia
- Neoplasm Metastasis
- Intrahepatic Cholangiocarcinoma
- Gastrointestinal Stromal Tumors
- Colonic Neoplasms
- Malignant Paraganglionic Neoplasm
Pathways
- Cell Motility
- Cell Differentiation
- Localization
- Chemotaxis
- Immune Response
- Segmentation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPBG
bosterbio.com/bosterbio-gene-info-cards/TPBG
References
PMID: 8132670 by Myers K.A., et al. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats.
PMID: 12481437 by Mulryan K., et al. Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors.