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- Table of Contents

Facts about Two pore calcium channel protein 2.
.
| Human | |
|---|---|
| Gene Name: | TPCN2 |
| Uniprot: | Q8NHX9 |
| Entrez: | 219931 |

| Belongs to: |
|---|
| calcium channel alpha-1 subunit (TC 1.A.1.11) family |

FLJ41094; SHEP10; TPC2two pore calcium channel protein 2; two pore segment channel 2; two-pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2
Mass (kDA):
85.243 kDA

| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (69048932..69090597) |
Widely expressed. Expressed at high level in liver and kidney.
Lysosome membrane; Multi-pass membrane protein. Only the acidic lysosomal fraction is sensitive to NAADP.





PMID: 19387438 by Calcraft P.J., et al. NAADP mobilizes calcium from acidic organelles through two-pore channels.
PMID: 19620632 by Brailoiu E., et al. Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.