Tripartite motif-containing protein 14 (TRIM14)

Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF- kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, resulting in the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373).

Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). .